Behavioral changes in exposure patterns after genetic counseling among asymptomatic first-degree relatives of patients with pulmonary fibrosis and carrier of a telomere-related gene variant
<title>Extract</title> Exposure to tobacco and profibrotic agents contributes to pulmonary fibrosis in relatives of patients carrying a telomere-related gene (TRG) variant [1]. Relatives may know their genetic status in cascade testing, and most of them don't report regret of having genetic testing whatever the results [2]. We hypothesized that the results of genetic cascade testing induces/triggers behavioral changes regarding environmental exposures. The study aims to describe past and current exposures among relatives of patients carrying a TRG variant and to compare behavior changes between carriers and non-carriers after genetic counselling.
Authors
- Diane Bouvry (ORCID: https://orcid.org/0000-0002-0557-5175)
- Stéphane Vagnarelli
- Vincent Cottin (ORCID: https://orcid.org/0000-0002-5591-0955)
- A Lassus
- Lucile Sesé (ORCID: https://orcid.org/0000-0002-6886-1793)
- Sonia Guéguen
- Lidwine Wémeau-Stervinou
- S. Jouneau (ORCID: https://orcid.org/0000-0002-1949-3461)
- Caroline Kannengiesser (ORCID: https://orcid.org/0000-0003-2155-9383)
- Bruno Crestani (ORCID: https://orcid.org/0000-0002-2961-3455)
- Philippe Bonniaud (ORCID: https://orcid.org/0000-0002-3670-5622)
- Raphaël Borie (ORCID: https://orcid.org/0000-0002-9906-0024)
- Grégoire Prévôt (ORCID: https://orcid.org/0000-0002-5014-9730)
- Hilario Nunes
- Cécile Guerin
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Hôpital Armand-Trousseau (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital d'Enfants (FR)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- CHU Dijon Bourgogne (FR)
- Hôpital Pontchaillou (FR)
- Hôpital Larrey (FR)
- Hôpital Avicenne (FR)
- Hôpital Louis Pradel (FR)
- Groupe Hospitalier de l'Institut Catholique de Lille (FR)
- Hôpital Bichat-Claude-Bernard (FR)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1183/23120541.01396-2025
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.16