Modulation of Pain Sensitivity by the Locus Coeruleus–Paraventricular Thalamic Nucleus–Anterior Cingulate Cortex Pathway in Mice
This study identified the LC-PVA-ACC pathway as a hierarchical noradrenergic circuit that modulates nociceptive sensitization via a thalamocortical relay, thereby revealing a circuit-specific mechanism by which the locus coeruleus-norepinephrine system regulates pain processing.
Authors
- Pingting Yang (ORCID: https://orcid.org/0000-0002-2800-7947)
- Kechao Tang (ORCID: https://orcid.org/0000-0003-4570-0142)
- Nanjue Cao (ORCID: https://orcid.org/0000-0001-6994-5924)
- Ping Zhao (ORCID: https://orcid.org/0000-0001-6392-5391)
- Ziyi Wu (ORCID: https://orcid.org/0000-0001-5911-9127)
- Yong-Da Liu (ORCID: https://orcid.org/0000-0002-1544-9455)
- Xueru Wang (ORCID: https://orcid.org/0009-0008-3762-8252)
- Ling Qin (ORCID: https://orcid.org/0000-0001-8717-3833)
- Shihui Kuai
- Xuejiao Wang (ORCID: https://orcid.org/0000-0002-3273-280X)
- Zijie Li (ORCID: https://orcid.org/0000-0002-2448-1246)
- Xu Y (ORCID: https://orcid.org/0009-0001-3498-7494)
- Shiyue Fan
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1097/aln.0000000000005897
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00