Relative contribution of gonads and sex chromosomes to sex differences in cell-type gene expression in the mouse medial septum and sex-biased disease risk
Our findings challenge the classical gonad-centric views of sexual differentiation, as the MS displays sex-biased transcriptional regulation driven by sex chromosome-associated effects that are highly relevant for human health.
Authors
- Haley Hrncir
- Caden N. McQuillen (ORCID: https://orcid.org/0000-0002-7762-9283)
- Juliana Shin (ORCID: https://orcid.org/0009-0003-4383-0338)
- Allan MacKenzie‐Graham (ORCID: https://orcid.org/0000-0001-9966-2335)
- Graciel Diamante (ORCID: https://orcid.org/0000-0002-2433-6161)
- Montgomery Blencowe (ORCID: https://orcid.org/0000-0001-7147-1895)
- Arthur P. Arnold (ORCID: https://orcid.org/0000-0002-9908-9767)
- Jason P. Lerch (ORCID: https://orcid.org/0000-0002-4871-8578)
- Armin Raznahan (ORCID: https://orcid.org/0000-0002-5622-1190)
- X. Chen (ORCID: https://orcid.org/0009-0003-8483-6162)
- Yang Xia (ORCID: https://orcid.org/0000-0003-2487-2244)
- Guanglin Zhang (ORCID: https://orcid.org/0000-0001-7248-4874)
- In Sook Ahn
Institutions
- UCLA Health (US)
- University of Oxford (GB)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-11
- DOI
- https://doi.org/10.64898/2025.12.08.693050
- Citations
- 1
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 1.82