Extracellular Matrix Deposition Drives Disease Progression and Reduces Rapamycin Response in LAM
Extracellular matrix deposition upregulates the expression of genes which may blunt the response to rapamycin but offer additional therapeutic opportunities for patients with established LAM.
Authors
- Simon R. Johnson (ORCID: https://orcid.org/0000-0002-9837-2763)
- Lee A. Borthwick (ORCID: https://orcid.org/0000-0003-2885-3382)
- Debbie Clements (ORCID: https://orcid.org/0000-0003-1902-6860)
- Roya Babaei‐Jadidi (ORCID: https://orcid.org/0009-0007-5001-3124)
- Diana Julie Leeming (ORCID: https://orcid.org/0000-0002-4256-140X)
- Nurul Syazana Mohamad Shah
- Jannie Marie Bülow Sand (ORCID: https://orcid.org/0000-0002-3239-0934)
- Andrew J. Fisher (ORCID: https://orcid.org/0000-0003-4822-7223)
- Antoine Dufour (ORCID: https://orcid.org/0000-0002-3429-4188)
- Jan Johnson
- S. Miller (ORCID: https://orcid.org/0000-0001-8508-1871)
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Calgary (CA)
- Freeman Hospital (GB)
- Nordic Bioscience (Denmark) (DK)
- Nottingham Biomedical Research Centre (GB)
- Newcastle University (GB)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1183/13993003.00492-2025
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00