The phytochemical arbutin exerts potent anti-Toxoplasma effects through activation of cell-autonomous defense mechanisms while attenuating inflammation
Our data highlight arbutin's potential therapeutic value in fighting against acute hyperinflammatory phase of Toxoplasmosis even in immunocompromised host but also its limitation in establishing long-term immunity. Our study further suggests a potential direction for further development of effective drugs to prevent and treat toxoplasmosis by pharmacologically enhancing cell-autonomous defense mechanisms while suppressing inflammatory response.
Authors
- Zhu Xiao (ORCID: https://orcid.org/0000-0001-5645-160X)
- Yusi Shen (ORCID: https://orcid.org/0000-0001-7793-6059)
- Zhuan-Zhuan Liu (ORCID: https://orcid.org/0000-0002-9453-9714)
- Yu‐Lu Ma (ORCID: https://orcid.org/0000-0003-0418-0638)
- Yanbo Kou (ORCID: https://orcid.org/0000-0002-8794-4711)
- Zhen Shi (ORCID: https://orcid.org/0009-0006-7270-1166)
- Yugang Wang (ORCID: https://orcid.org/0000-0003-4687-4742)
- Yaoyao Xiang
- Yanxia Wei (ORCID: https://orcid.org/0000-0003-2706-957X)
- Longxiang Liao
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1371/journal.pntd.0013815
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00