Comparative Outcomes and Immune Mechanisms in Murine Endothelial Versus Penetrating Keratoplasty
EK grafts exhibit higher graft survival rates and significantly reduced activation of host T-cell responses compared with PK grafts, which may be attributed to lower frequencies of graft-borne antigen presenting cells, thus resulting in a milder Th1-mediated immune response.
Authors
- Seok-Joo Lee (ORCID: https://orcid.org/0009-0003-7317-2583)
- Reza Dana (ORCID: https://orcid.org/0000-0002-5732-5100)
- Shilpy Bhullar (ORCID: https://orcid.org/0000-0002-1698-2024)
- Akitomo Narimatsu (ORCID: https://orcid.org/0000-0002-0073-3162)
- Yihe Chen (ORCID: https://orcid.org/0000-0002-2336-6182)
- Rohan Bir Singh (ORCID: https://orcid.org/0000-0002-2426-3900)
Institutions
- Massachusetts Eye and Ear Infirmary (US)
Publication Details
- Journal
- Cornea
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1097/ico.0000000000004046
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00