Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1α in stroke progression
Our findings underscore the significant role of genetic determinants in chromosome 9p21, the lncRNA-ANRIL, HNF1α-A > C (p.I27L), and PAI-1-4G > 5G genes in elevating the risk of stroke. Additionally, we report low, novel, and intermediate-genetic-risk variants in COL4A2, PSEN2, NOTCH3, and RNF2 through WES, emphasizing the need for further investigation in larger cohort studies.
Authors
- Osama M. Al‐Amer (ORCID: https://orcid.org/0000-0002-1533-8181)
- Muthupandian Saravanan (ORCID: https://orcid.org/0000-0002-1480-3555)
- Sael Alatawi (ORCID: https://orcid.org/0000-0001-5773-5567)
- Waseem AlZamzami (ORCID: https://orcid.org/0000-0002-6673-6649)
- Imadeldin Elfaki (ORCID: https://orcid.org/0000-0003-2752-830X)
- Atif Abdulwahab A. Oyouni (ORCID: https://orcid.org/0000-0001-8762-4999)
- Rashid Mir (ORCID: https://orcid.org/0000-0003-2068-3075)
- Abdullah Hamadi (ORCID: https://orcid.org/0000-0002-1095-5455)
- Mohammed Alasseiri (ORCID: https://orcid.org/0000-0003-0406-1524)
- Gasim Dobie (ORCID: https://orcid.org/0000-0002-9225-1709)
- Mohammad Alanazi (ORCID: https://orcid.org/0000-0001-6766-3237)
Institutions
- Fahd bin Sultan University (SA)
- University of Tabuk (SA)
- Jazan University (SA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1371/journal.pone.0332252
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00