SportsXbiodata: A web platform for integrative analysis of exercise-induced gene and protein expression

Exercise can induce extensive molecular adaptations across multiple tissues; however, existing databases primarily focus on transcriptomic data and lack the ability to integrate multi-omics evidence and literature within a systems biology framework. To address this limitation, we developed SportsXbiodata, an open-access multi-omics integration platform that compiles 2,563 public multi-omics datasets and 3,600 exercise-related publications. The platform provides comprehensive functional modules for gene/protein/metabolite expression profiling, immune infiltration analysis, phenotype-gene correlation analysis, knowledge graph analysis, literature-based gene exploration, and exercise-drug homology analysis. It also supports data querying, visualization, and user-defined enrichment analysis for exercise-related datasets. SportsXbiodata is completely free and accessible without registration, allowing users to directly download standardized datasets and analysis results, thereby promoting transparency and reproducibility in scientific research.