Metachronous Presentation of BCL-2-Positive Lung Adenocarcinoma and Acute Myeloid Leukemia: A Case Presentation and Review of the Literature
This salvage regimen successfully induced a second CR in the refractory AML. This case highlights the complexity of managing these distinct malignancies, where the lung tumor's BCL-2 expression provided a rationale for the AML therapy. Furthermore, the MiniPDX assay proved valuable in guiding personalized therapy for refractory disease, demonstrating the potential of functional precision medicine strategies.
Authors
- Ling Zhu (ORCID: https://orcid.org/0000-0002-6559-0967)
- Hongyan Lan
- Bo Zheng (ORCID: https://orcid.org/0000-0002-1496-0753)
- Jie-Yi Zhou (ORCID: https://orcid.org/0009-0007-4241-4083)
- Chengyang Xu (ORCID: https://orcid.org/0000-0001-6188-8101)
- Rong Li (ORCID: https://orcid.org/0000-0002-1805-810X)
- Chen Chen (ORCID: https://orcid.org/0000-0002-3766-6151)
- Yajun Zhang (ORCID: https://orcid.org/0000-0003-2632-409X)
- Jiale Chen (ORCID: https://orcid.org/0000-0002-4819-4911)
- Miaomiao Chen (ORCID: https://orcid.org/0000-0002-4866-8072)
- Min Yu (ORCID: https://orcid.org/0000-0003-1875-740X)
- Ke Yi (ORCID: https://orcid.org/0000-0003-2044-6870)
- Jie He (ORCID: https://orcid.org/0000-0002-1326-4166)
- Ce Xu (ORCID: https://orcid.org/0009-0007-0430-4422)
- Tongfang Pang
Institutions
- PLA Navy General Hospital (CN)
Publication Details
- Journal
- Case Reports in Oncology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1159/000549934
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China