Allopurinol Use Is Associated with Decreased Incidence of Hepatic Decompensation and Overall Mortality among Individuals with Cirrhosis: A Propensity-Matched Cohort Study

In a propensity score-matched analysis of a large national database, individuals with cirrhosis and allopurinol use had significantly lower risk of hepatic decompensation and overall mortality. These findings suggest that allopurinol may play a potential role in managing cirrhosis, and randomized clinical trials are needed to confirm these findings.

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Publication Details

Journal
GE Portuguese Journal of Gastroenterology
Published
2025-12-11
DOI
https://doi.org/10.1159/000549923
Primary Topic
Liver Disease and Transplantation
Type
article
Field-Weighted Citation Impact
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article

Allopurinol Use Is Associated with Decreased Incidence of Hepatic Decompensation and Overall Mortality among Individuals with Cirrhosis: A Propensity-Matched Cohort Study

Shahem Abbarh, Alex P. Salam, Mohammed Abu‐Rumaileh, Muhammed Elhadi et al.
GE Portuguese Journal of Gastroenterology
Liver Disease and Transplantation
article

Allopurinol Use Is Associated with Decreased Incidence of Hepatic Decompensation and Overall Mortality among Individuals with Cirrhosis: A Propensity-Matched Cohort Study

Shahem Abbarh, Alex P. Salam, Mohammed Abu‐Rumaileh, Muhammed Elhadi, Monica A. Tincopa, Mouaz Haffar, Bisher Sawaf, Yusuf O. Hallak, Mohammed S. Beshr, Mulham Alom, Mohammad Al Hayek, Ahmad Kassem, Rana H. Shembesh, Elias Batikh
article en

Abstract

In a propensity score-matched analysis of a large national database, individuals with cirrhosis and allopurinol use had significantly lower risk of hepatic decompensation and overall mortality. These findings suggest that allopurinol may play a potential role in managing cirrhosis, and randomized clinical trials are needed to confirm these findings.

GE Portuguese Journal of Gastroenterology
University of California, Los Angeles (US), Sana'a University (YE), Georgetown University (US), Southern Illinois University School of Medicine (US), Korea University (KR), John H. Stroger, Jr. Hospital of Cook County (US), MedStar Georgetown University Hospital (US), West Virginia University Hospitals (US), University of California San Diego (US), Sağlık Bilimleri Üniversitesi (TR), Libyan International Medical University (LY), MedStar Health (US), University of Health Sciences Antigua (AG), Damascus University (SY), University of Toledo (US)
Openalex Percentile: Top 47%
Liver Disease and Transplantation
DOIOpen Access PDFOpenAlex
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