UCP2-Driven Fatty Acid Oxidation Promotes Macrophage M2 Polarization and Renal Fibrosis
In summary, we identified UCP2 as a key regulator of macrophage metabolic reprogramming and a critical promoter of renal fibrosis, suggesting that targeting UCP2 represents a promising therapeutic strategy.
Authors
- Lei Jiang (ORCID: https://orcid.org/0000-0002-7322-4502)
- Xinyan Gu
- Xingyue Wang (ORCID: https://orcid.org/0000-0003-1177-539X)
- Libo Liu (ORCID: https://orcid.org/0000-0001-5773-0184)
- Yuxi Li (ORCID: https://orcid.org/0000-0002-6468-5454)
- Chunsun Dai (ORCID: https://orcid.org/0000-0001-7616-2469)
Institutions
- Second Affiliated Hospital of Nanjing Medical University (CN)
Publication Details
- Journal
- Kidney Diseases
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1159/000549918
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province