Neonatal Aortic Nonbacterial Thrombotic Endocarditis: Successful Surgical Management of a Rare Case

Nonbacterial thrombotic endocarditis (NBTE) is an extremely rare and usually fatal condition in neonates, characterized by sterile fibrin-platelet vegetations on cardiac valves. We report a term male neonate with severe left ventricular outflow tract and aortic valve obstruction due to a 7 × 8 mm mass. Urgent surgical resection preserved valve anatomy, and recovery was uneventful; histopathology confirmed NBTE. Differential diagnosis of neonatal cardiac masses, including rhabdomyomas, fibroelastomas, and thrombi, is crucial. Early echocardiographic recognition, prostaglandin support, and timely surgery can enable survival despite an otherwise poor prognosis.

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Publication Details

Journal
World Journal for Pediatric and Congenital Heart Surgery
Published
2025-12-11
DOI
https://doi.org/10.1177/21501351251396556
Primary Topic
Infective Endocarditis Diagnosis and Management
Type
article
Field-Weighted Citation Impact
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article

Neonatal Aortic Nonbacterial Thrombotic Endocarditis: Successful Surgical Management of a Rare Case

Rodrigo Molinas, Ignacio Juaneda, Paolo Albino Ferrari, González Carranza et al.
World Journal for Pediatric and Congenital Heart Surgery
Infective Endocarditis Diagnosis and Management
article

Neonatal Aortic Nonbacterial Thrombotic Endocarditis: Successful Surgical Management of a Rare Case

Rodrigo Molinas, Ignacio Juaneda, Paolo Albino Ferrari, González Carranza, Carlos Resino, Alejandro Allub, Alejandro Peirone
article en

Abstract

Nonbacterial thrombotic endocarditis (NBTE) is an extremely rare and usually fatal condition in neonates, characterized by sterile fibrin-platelet vegetations on cardiac valves. We report a term male neonate with severe left ventricular outflow tract and aortic valve obstruction due to a 7 × 8 mm mass. Urgent surgical resection preserved valve anatomy, and recovery was uneventful; histopathology confirmed NBTE. Differential diagnosis of neonatal cardiac masses, including rhabdomyomas, fibroelastomas, and thrombi, is crucial. Early echocardiographic recognition, prostaglandin support, and timely surgery can enable survival despite an otherwise poor prognosis.

World Journal for Pediatric and Congenital Heart Surgery
Hospital de Niños de la Santísima Trinidad (AR)
Openalex Percentile: Top 49%
Infective Endocarditis Diagnosis and Management
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Neonatal Aortic Nonbacterial Thrombotic Endocarditis: Successful Surgical Management of a Rare Case — Rodrigo Molinas, Ignacio Juaneda, et al. · World Journal for Pediatric and Congenital Heart Surgery (2025) | TGRS Research Map | TGRS