Integrated transcriptomic and metabolomic analyses reveal the antibacterial mechanism of isocorydine against Mycobacterium bovis
Our results demonstrate that ICD exerts its antibacterial effect primarily by targeting the cell envelope, causing membrane disruption and energetic stress. <i>M. bovis</i> responds by activating efflux pumps and reprogramming its metabolism. This multi-omics study reveals the potential of ICD as an anti-mycobacterial agent and provides novel insights into the adaptive strategies of M. bovis under phytochemical stress.
Authors
- Wang Ting-pu
- Yanmei Liu (ORCID: https://orcid.org/0000-0002-6478-7063)
- Yijun Yuan
- Peng Wang (ORCID: https://orcid.org/0000-0003-4250-8104)
- Xia Wang (ORCID: https://orcid.org/0000-0002-8456-3921)
- Xiang Gao (ORCID: https://orcid.org/0000-0003-2617-6509)
- Weichao Ma (ORCID: https://orcid.org/0000-0003-3237-2346)
- Tianyu Zhao (ORCID: https://orcid.org/0000-0003-3845-9119)
Institutions
- Tianshui Normal University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.3389/fmicb.2025.1717499
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00