Chorioretinal Atrophy after Voretigene Neparvovec Therapy in RPE65 Mutation-Associated Inherited Retinal Disease: Longitudinal Characterization in Multimodal Imaging
This study highlights the crucial role of multimodal imaging in monitoring VN-associated CRA. Differences in lesion detection and size assessment across imaging modalities were observed, with the largest CRA extent detected in BAF imaging. Median visual function remained stable. These findings emphasize the complexity of VN therapy outcomes and the need for close surveillance using combined multimodal imaging to better understand the long-term clinical implications. .
Authors
- Frank Gerhard Holz (ORCID: https://orcid.org/0000-0001-8019-9272)
- Markus N. Preising (ORCID: https://orcid.org/0000-0002-1596-5978)
- Birgit Lorenz (ORCID: https://orcid.org/0000-0002-9737-8127)
- Josua Sassen (ORCID: https://orcid.org/0000-0002-8069-4713)
- Marlene Saßmannshausen (ORCID: https://orcid.org/0000-0001-5265-4645)
- Johanna P. Scholz
- Philipp Herrmann
- Sandrine H. Sassen
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Bonn (DE)
- Inserm (FR)
- Justus-Liebig-Universität Gießen (DE)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
Publication Details
- Journal
- Ophthalmologica
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1159/000549548
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00