Zinc and Type 2 Diabetes: A Systematic Review with a Narrative Synthesis of Their Bidirectional Relationship and Clinical Perspectives for Personalized Nutritional Support
Zinc is mechanistically involved in insulin synthesis, antioxidant defense, and inflammation control, but current clinical evidence does not justify its use as a therapeutic agent in T2DM. Instead, assessment of zinc status and individualized correction of deficiency may represent a component of personalized nutritional support, particularly for patients with long disease duration, poor dietary quality, or genetic predispositions affecting zinc metabolism.
Authors
- Alexander N. Kosenkov
- Sherzodkhon Mutallibzoda (ORCID: https://orcid.org/0000-0003-3855-9494)
- Evgeniya Klein (ORCID: https://orcid.org/0000-0003-0322-036X)
- Svetlana Tefikova (ORCID: https://orcid.org/0000-0001-9086-0781)
- Д. А. Куликов (ORCID: https://orcid.org/0000-0002-4273-8295)
- D. A. Velina (ORCID: https://orcid.org/0000-0002-2398-3375)
- Olga Orlovtseva (ORCID: https://orcid.org/0000-0002-3796-1679)
- Игорь Алексеевич Никитин (ORCID: https://orcid.org/0000-0002-8988-5911)
Institutions
- Plekhanov Russian University of Economics (RU)
- Sechenov University (RU)
- All-Russian Scientific Research Institute of Food Biotechnology (RU)
Publication Details
- Journal
- Diseases
- Published
- 2025-12-11
- DOI
- https://doi.org/10.3390/diseases13120396
- Citations
- 1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12