Grain proteins ameliorate glucose metabolism disorders by activating intestinal AhR and the hepatic NLK/FOXO1 pathway via gut microbiota-derived indole metabolites
Grain proteins alleviate glucose metabolic disorders by enriching gut microbiota-derived indole metabolites, which improve intestinal homeostasis and inhibit hepatic gluconeogenesis through AhR and NLK/FOXO1 signaling. These findings highlight the therapeutic potential of grain proteins for T2D prevention and management.
Authors
- Yong Xue (ORCID: https://orcid.org/0000-0002-6376-5006)
- Zijian Dai (ORCID: https://orcid.org/0009-0006-6532-4446)
- Yumei Zhang
- Xin Bao
- Hua Jiang (ORCID: https://orcid.org/0000-0003-1483-3380)
- Qun Shen
Institutions
- Peking University (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.010
- Citations
- 1
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81