Prebiopsy Steroids and Diagnostic Yield in Patients With Diffuse Large B-Cell Lymphoma

In this case series of 320 patients with DLBCL, prebiopsy corticosteroid administration was not associated with reduced diagnostic yield or delay in treatment in patients with newly diagnosed DLBCL. Biopsy technique was most associated with diagnostic success. These findings support a clinically pragmatic approach to steroid use during lymphoma evaluation.

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Publication Details

Journal
JAMA Network Open
Published
2025-12-11
DOI
https://doi.org/10.1001/jamanetworkopen.2025.48617
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Prebiopsy Steroids and Diagnostic Yield in Patients With Diffuse Large B-Cell Lymphoma

Charles Milrod, Ari Pelcovits, Christina Raker, Kelly Pan et al.
JAMA Network Open
Lymphoma Diagnosis and Treatment
article

Prebiopsy Steroids and Diagnostic Yield in Patients With Diffuse Large B-Cell Lymphoma

Charles Milrod, Ari Pelcovits, Christina Raker, Kelly Pan, Sovijja Pou, Kaavya Mandi, Sathwik Madireddy, Ross Terada, Ding Huang, Alex Friefeld
article en

Abstract

In this case series of 320 patients with DLBCL, prebiopsy corticosteroid administration was not associated with reduced diagnostic yield or delay in treatment in patients with newly diagnosed DLBCL. Biopsy technique was most associated with diagnostic success. These findings support a clinically pragmatic approach to steroid use during lymphoma evaluation.

JAMA Network OpenVol. 8(12)
Brown University (US)
Brown University
Openalex Percentile: Top 45%
Lymphoma Diagnosis and Treatment
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