Testosterone and Long-Pulse-Width Stimulation (TLPS) on Denervated Muscles and Cardio-Metabolic Risk Factors After Spinal Cord Injury: A Pilot Randomized Trial
These pilot data demonstrated the safety of applying LPWS in persons with SCI. Six months of TT + LPWS demonstrated increases in rectus femoris muscle CSA. The effects on muscle size were modest between groups. Signaling pathway analysis suggested downregulation of genes involved in muscle atrophy pathways. Future clinical trials may consider a home-based approach with more frequent applications of LPWS.
Authors
- Ranjodh Gill (ORCID: https://orcid.org/0000-0003-0195-9646)
- Ashraf S. Gorgey (ORCID: https://orcid.org/0000-0002-9157-6034)
- Edward J. Lesnefsky (ORCID: https://orcid.org/0000-0002-9672-7065)
- Lance L. Goetz (ORCID: https://orcid.org/0000-0003-4250-551X)
- Michael J. McClure (ORCID: https://orcid.org/0000-0002-5428-5270)
- Robert A. Adler (ORCID: https://orcid.org/0000-0002-2019-0417)
- Ryan S. Garten (ORCID: https://orcid.org/0000-0002-8939-6093)
- Ahmad Alazzam
- Teodoro Castillo
- James T. Redden
- Deborah Caruso
- Jeannie Rivers (ORCID: https://orcid.org/0000-0002-8553-8648)
- Qun Chen (ORCID: https://orcid.org/0000-0001-5683-7844)
- Refka E. Khalil
Institutions
- Virginia Commonwealth University (US)
- Spinal Injuries Center (JP)
- Virginia Commonwealth University Medical Center (US)
Publication Details
- Journal
- Cells
- Published
- 2025-12-11
- DOI
- https://doi.org/10.3390/cells14241974
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00