Evaluation of Pafolacianine (Cytalux®) for Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma: A Negative Study with Important Clinical Implications
Negative studies such as this are essential for evidence-based clinical decision-making, preventing unnecessary resource allocation and potential patient exposure to ineffective interventions. These findings inform the broader fluorescence-guided surgery field and support continued investigation of alternative targeting strategies for HNSCC.
Authors
- Syed Ziauddin A. Zaidi (ORCID: https://orcid.org/0000-0001-9075-8752)
- Marisa E. Hom (ORCID: https://orcid.org/0000-0003-1319-5110)
- Abdullah Naveed (ORCID: https://orcid.org/0000-0002-0237-5434)
- Connor Burns (ORCID: https://orcid.org/0009-0008-9365-3612)
- Hidenori Tanaka (ORCID: https://orcid.org/0000-0001-6169-290X)
- Lucas Mani (ORCID: https://orcid.org/0009-0002-8638-4705)
- Eben Lloyd Rosenthal (ORCID: https://orcid.org/0000-0003-0294-5203)
- Ashtyn McAdoo
- Estelle Martin
Institutions
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1007/s11307-025-02068-3
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- Vanderbilt University Medical Center