S2730 Long Term Mortality Trends in GI Neoplasms With Liver Metastases: Insight From CDC Data (1999-2020)

Introduction: Gastrointestinal (GI) cancers cause significant cancer-related deaths worldwide, with liver metastases contributing heavily to mortality. This study analyzes mortality trends from 1999 to 2020. Methods: CDC WONDER mortality data (1999–2020) were retrospectively analyzed. Age-adjusted mortality rates (AAMRs) per 100,000 for liver metastasis were calculated. Trends were assessed by Annual Percent Change (APC), stratified by age, sex, race/ethnicity, and region. Results: Between 1999 and 2020, 201,843 deaths due to liver metastasis in GI neoplasm patients aged ≥25 were recorded in the U.S. Joinpoint regression showed a steady decline in AAMR from 1999 to 2008 (APC: -6.3171; 95% CI: 6.85–5.89), followed by a sharp increase from 2016 to 2020 (APC: 4.85; 95% CI: 3.15–5.74). Men had higher mortality increases (APC: 4.99; 95% CI: 3.25–6.00) than women (APC: 4.37; 95% CI: 1.70–5.65). By race/ethnicity, AAMR was highest among non-Hispanic Black/African Americans (APC: 3.69; 95% CI: 2.31–5.86), followed by non-Hispanic Whites (APC: 5.43; 95% CI: 4.03–6.24), Hispanics/Latinos (APC: 5.52; 95% CI: 4.48–7.10), Asians/Pacific Islanders (APC: 7.65; 95% CI: 4.69–15.42), and American Indians/Alaskan Natives (APC: 5.63; 95% CI: 2.54–15.42). Regionally, the Midwest had the highest mortality increase (APC: 6.55; 95% CI: 3.86–8.23), followed by the West (APC: 1.59; 95% CI: 1.74–5.74), South (APC: 2.11; 95% CI: 1.47–4.53), and Northeast (APC: 9.00; 95% CI: 1.85–12.58). Non metropolitan areas showed higher mortality increases (APC: 7.19; 95% CI: 6.25–8.69) than metropolitan areas (APC: 3.85; 95% CI: 0.97–6.14). Conclusion: This study highlights a marked rise in liver metastasis-related mortality among U.S. adults with GI neoplasms since 2006. It underscores the need for targeted public health efforts to address disparities and improve outcomes in underserved populations.