Regional Differences in Calcium Dynamics in the Intact Lens: The Role of TRPV Channels in Lens Calcium Regulation
This study establishes a confocal imaging approach for simultaneous analysis of Ca²⁺ dynamics in epithelial and fiber cells of the intact lens. Our findings reveal region-specific differences in Ca²⁺ regulation and provide insight into how TRPV1 and TRPV4 activate signaling pathways that regulate lens ion homeostasis and water transport to maintain optical properties.
Authors
- Paul J. Donaldson (ORCID: https://orcid.org/0000-0002-4008-1138)
- Kevin F. Webb (ORCID: https://orcid.org/0000-0002-0858-304X)
- Yadi Chen (ORCID: https://orcid.org/0009-0008-1007-806X)
Institutions
- University of Nottingham (GB)
- University of Auckland (NZ)
- Applied Photonics (United Kingdom) (GB)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1167/iovs.66.15.37
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Research Council of New Zealand