Trigeminal ganglion interferon-γ signaling drives orofacial neuropathic pain in rats
CD8⁺ T cell-derived IFN-γ activates SGCs in the TG, leading to IL-1β release that promotes neuronal hyperactivity and orofacial neuropathic pain following IONI. Targeting the IFN-γ-SGC-IL-1β signaling axis may represent a novel therapeutic strategy for orofacial neuropathic pain.
Authors
- Masamichi Shinoda (ORCID: https://orcid.org/0000-0003-0965-6498)
- Suzuro Hitomi (ORCID: https://orcid.org/0000-0003-3311-1519)
- Akiko Okada‐Ogawa (ORCID: https://orcid.org/0000-0002-4309-7100)
- Momoyo Kobayashi
- Hiromasa Tsuda (ORCID: https://orcid.org/0000-0002-2047-2262)
- Yukinori Tanaka (ORCID: https://orcid.org/0000-0001-6170-2960)
- Koichi Iwata (ORCID: https://orcid.org/0000-0001-5859-9237)
- Noboru Noma (ORCID: https://orcid.org/0000-0001-5405-0407)
- Yoshinori Hayashi (ORCID: https://orcid.org/0000-0002-7750-0674)
- Kentaro Mizuta (ORCID: https://orcid.org/0000-0001-8963-9844)
- Asako Kubo (ORCID: https://orcid.org/0009-0009-4475-1918)
Institutions
- Nihon University (JP)
- Tohoku University (JP)
- Niigata University of Health and Welfare (JP)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1186/s10194-025-02242-6
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00