Effectiveness of 2024–2025 COVID-19 Vaccines in Children in the United States — VISION, August 29, 2024–September 2, 2025
During September 2023-August 2024, approximately 38,000 COVID-19-associated hospitalizations occurred among children and adolescents aged <18 years in the United States, a rate of approximately 53 per 100,000 children, ranging from 600 per 100,000 children aged <6 months to 21 per 100,000 children and adolescents aged 5-17 years. On June 27, 2024, the Advisory Committee on Immunization Practices recommended that all persons aged ≥6 months receive a 2024-2025 COVID-19 vaccine, which targeted Omicron JN.1 and JN.1-derived sublineages. Investigators used a test-negative case-control design to estimate vaccine effectiveness (VE) of 2024-2025 COVID-19 vaccines against COVID-19-associated emergency department or urgent care (ED/UC) visits during August 29, 2024-September 2, 2025, among immunocompetent children aged 9 months-4 years and children and adolescents aged 5-17 years in the CDC-funded Virtual SARS-CoV-2, Influenza, and Other respiratory viruses Network (VISION), a multisite electronic health record-based network in nine states. Among children aged 9 months-4 years, VE against COVID-19-associated ED/UC visits was estimated at 76% (95% CI = 58%-87%) during the first 7-179 days after vaccination. Among children and adolescents aged 5-17 years, VE against COVID-19-associated ED/UC visits was an estimated 56% (95% CI = 35%-70%) during the first 7-179 days after vaccination. These findings suggest that vaccination with a 2024-2025 COVID-19 vaccine dose provided children with additional protection against COVID-19-associated ED/UC encounters compared with no 2024-2025 dose.
Authors
- Josephine Mak (ORCID: https://orcid.org/0000-0001-9557-2690)
- Christian M. Rogerson (ORCID: https://orcid.org/0000-0003-1306-8867)
- Toan C. Ong (ORCID: https://orcid.org/0000-0001-6787-1407)
- Allison L. Naleway (ORCID: https://orcid.org/0000-0001-5747-4643)
- Catia Chávez
- Pradeep Koppolu (ORCID: https://orcid.org/0000-0001-8226-6926)
- Inih Essien (ORCID: https://orcid.org/0000-0003-0775-8255)
- David Mayer (ORCID: https://orcid.org/0000-0002-6056-9771)
- Ousseny Zerbo (ORCID: https://orcid.org/0000-0002-8380-6215)
- Brian E. Dixon (ORCID: https://orcid.org/0000-0002-1121-0607)
- Sarah E. Reese (ORCID: https://orcid.org/0000-0002-2127-1454)
- Ruth Link‐Gelles (ORCID: https://orcid.org/0000-0002-9617-806X)
- Ryan E. Wiegand (ORCID: https://orcid.org/0000-0002-9486-1850)
- Amber Kautz (ORCID: https://orcid.org/0000-0001-8463-9167)
- Michelle A. Barron (ORCID: https://orcid.org/0000-0002-8217-7410)
- Nicola P. Klein (ORCID: https://orcid.org/0000-0003-1777-4814)
- Karen B. Jacobson (ORCID: https://orcid.org/0000-0003-3050-4595)
- Malini B. DeSilva (ORCID: https://orcid.org/0000-0003-3705-1672)
- John Hansen (ORCID: https://orcid.org/0000-0001-7891-2673)
- Zachary A. Weber (ORCID: https://orcid.org/0000-0001-6896-5050)
- Sarah W. Ball (ORCID: https://orcid.org/0000-0002-0903-8107)
- Elizabeth A. K. Rowley (ORCID: https://orcid.org/0000-0002-0593-1096)
- Shaun J. Grannis (ORCID: https://orcid.org/0000-0002-8093-6639)
- Stephanie A. Irving (ORCID: https://orcid.org/0000-0001-7437-6797)
- Julie Arndorfer
- Daniel Bride (ORCID: https://orcid.org/0000-0002-7950-1267)
- Ashley Stephens (ORCID: https://orcid.org/0000-0002-0588-1463)
- Tom Duszynski
- Karthik V. Natarajan (ORCID: https://orcid.org/0000-0002-9066-9431)
- Melissa S. Stockwell (ORCID: https://orcid.org/0000-0002-2113-7247)
- Jennifer DeCuir (ORCID: https://orcid.org/0000-0001-5071-3875)
- Kristin Dascomb (ORCID: https://orcid.org/0000-0002-7422-060X)
- Amanda B. Payne (ORCID: https://orcid.org/0000-0003-1027-7639)
- Tamara Sheffield
- Lawrence Block
- Josh Van Otterloo
- Sean Chickery (ORCID: https://orcid.org/0000-0002-2135-0355)
Institutions
- Intermountain Healthcare (US)
- Kaiser Permanente (US)
Publication Details
- Journal
- MMWR Morbidity and Mortality Weekly Report
- Published
- 2025-12-11
- DOI
- https://doi.org/10.15585/mmwr.mm7440a1
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- U.S. Department of Health and Human Services
- Kaiser Permanente
- Centers for Disease Control and Prevention
- School of Medicine, Indiana University
- Irving Medical Center, Columbia University
- National Center for Immunization and Respiratory Diseases