Mechanism of Hypoxia‐Induced <scp>HMGB1</scp> Regulating <scp>NLRP3</scp> Inflammasome/Caspase‐1 Pathway‐Mediated Pyroptosis in Myocardial Ischemia Reperfusion Injury Through the Nrf2/ <scp>HO</scp> ‐1 Pathway
Hypoxia induces HMGB1's nucleus-to-cytoplasm translocation, which binds to Nrf2 to repress Nrf2 nuclear translocation to suppress Nrf2/HO-1 activation to promote NLRP3 inflammasome/Caspase-1-mediated pyroptosis, thereby exacerbating MIRI.
Authors
- G. Weng (ORCID: https://orcid.org/0009-0000-4382-899X)
- Licheng Yan
- Yongrong Lan
- Fuzhen Zheng (ORCID: https://orcid.org/0009-0001-9503-2093)
- Hongsong Chen (ORCID: https://orcid.org/0000-0002-0310-0088)
- Fei Ren (ORCID: https://orcid.org/0000-0001-6038-2598)
- Qian Chen (ORCID: https://orcid.org/0000-0002-3585-305X)
- Wenlong Cai
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/cns.70661
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00