S2485 Elevated ALP and Heart Attack Risk: A Nationwide Study Unveiling a Hidden Cardiovascular Threat

Introduction: Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, with traditional risk factors including hypertension, diabetes, and dyslipidemia. However, emerging research suggests that biochemical markers like alkaline phosphatase (ALP) may also play a critical role in the pathogenesis of MI. This study aims to explore the relationship between ALP levels and the incidence of MI, utilizing a large dataset from the Nationwide Admission Database (HCUP) spanning 2019 to 2024. By examining ALP levels in conjunction with MI events, this research seeks to establish whether elevated ALP can serve as a potential biomarker for increased cardiovascular risk. Methods: This study utilized data from the Nationwide Admission Database (HCUP) to analyze hospital admissions from 2019 to 2024, including 2,858,576 adults. ICD codes were used to retrieve patients from the HCUP database. Patients with ALP greater than 150 and any event of MI were included in the study. A propensity match was performed to match baseline characters. The primary aim was to evaluate the relation between ALP and Myocardial infarction. A contingency table was created to summarize the data distribution between the variables, and a chi-square test was performed to assess statistical significance. Results: The study included 103,457 patients, with women comprising 63,177 of the cohort (61%). The average ALP in the cohort was 175 ± 40. The analysis revealed a statistically significant relationship between increased ALP levels and myocardial infarction (MI), with a P-value of 0.0115. A chi-square test indicated a significant association, suggesting that higher ALP levels might be linked to a greater likelihood of MI. These findings highlight ALP as a potential biomarker for MI risk, emphasizing the need for further clinical research to explore the causation. Conclusion: This study reveals a significant association between elevated ALP levels and the risk of myocardial infarction (MI), suggesting ALP as a potential biomarker for MI. The statistically significant findings point to a possible mechanistic link that warrants further investigation. With rigorous data analysis, these results emphasize the need to consider ALP levels in cardiovascular risk assessments. Future research should explore the biological mechanisms, the long-term impact of ALP on MI, and potential interventions to reduce risk.