Chemistry and Utilities of Benzimidazole Derivatives and Their Different Applications in Heterocyclic Synthesis.

This review article covering the synthetic pathway leading to benzimidazole derivatives systems using simple reactive benzimidazole unit. Also, several benzimidazole with different substitutions at different position especially, 2- substituted ones were synthesized starting from o-phenylenediamine and different reagents.Benzimidazole derivatives have a wide applications in different fields as drugs, corrosion inhibitors and industrial field , food, pesticide, and veterinary and other fields. The biological activities of the synthesized compounds were examined and evaluated in vivo and vitro for large and different types of diseases and revealed good and promisiong results.Some examples of some benzimidazole derivatives that were established as drugs, corrosion inhibitors and in industrial field and other fields [88]. Therefore, the established potential biological activities of several benzimidazole derivatives have stimulated us to develop the chemistry of this class of compounds as useful building unit , precursors and important versatile reagent for the synthesis of many biologically interesting heterocyclic systems containing five, six and polyfunctionalized ones containing benzimidazole scaffold from available and readily obtainable inexpensive starting materials