Effect of Corneal Collagen Crosslinking for Treatment of Keratoconus on Topographic Indices Assessed by Scheimpflug Camera

Background: Keratoconus is a non-inflammatory bilateral corneal ectasia that produces myopia and uneven astigmatism. Corneal cross-linking (CXL) is new and exciting treatment option for keratoconus sufferers that has the potential to strengthen the cornea and stop the condition from worsening. Objectives: To assess and analyze alterations in corneal topographic parameters following CXL in patients diagnosed with keratoconus. Patients and methods: Fifty of the eyes who had keratoconus identified had CXL done. Using the Pentacam system, Seven indices were computed to measure parameters of corneal surface mapping: index of surface variance (ISV), index of vertical asymmetry (IVA), keratoconus index (KI), central keratoconus index (CKI), radius minimum (Rmin), index of height asymmetry (IHA), and index of height decentration (IHD). Patients were followed up for six months. Results: There was a significant difference between pre and after 1 m, after 3 m, and after 6 m, according to the following metrics: LogMAR uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), spherical equivalent (SE), ISV, IVA, KI, CKI, IHA, IHD, and Rmin. Pre- and after 6 months correlations between (LogMAR UCVA with SE, ISV, CKI, IHA, and IHD via change) and (LogMAR BCVA with SE, IVA, KI, IHA, and IHD through change) were statistically significant. Conclusions: Improvements were observed in four of the seven corneal surface mapping indices six months following CXL, demonstrating a comprehensive enhancement of corneal shape.