In conversation with Yu Cao: engineering tomorrow’s needle-to-cure therapeutics with in vivo CAR-T

Meet the Cell & Gene Therapy Insights Editorial BoardTo celebrate Cell & Gene Therapy Insights’ 10th anniversary, Editorial Advisory Board member Dr Yu (Clay) Cao reflects on a decade in cellular immunotherapy, viral and non-viral vectors, gene editing, and stem cell therapy. He highlights the emergence of in vivo CAR-T therapies, transformative regulatory approvals in 2025, and the expanding reach of RNA- and CRISPR-based approaches. Dr Cao shares his perspective on translating cutting-edge science into scalable, patient-ready therapies, offering advice for researchers navigating this rapidly evolving field.