The effect of intravenous granisetron versus intravenous dexmedetomidine on shivering following spinal anesthesia in the cesarean section.A randomized controlled comparative trial.

Background: Shivering is a usual complication for parturients and anesthesiologists during spinal anethesia. we evaluate the efficacy of granisetron versus dexmedetomidine as a prophylaxis against postspinal shivering. Objective: The main aim was to assess the efficacy of granisetron and dexmedetomidine in lowering the incidence and severity of postspinal shivering. Study design: Prospective, randomized, comparative, double blind, controlled study and 75 parturients participated. Method: This trial was accomplished on 75 parturients, ASA I-II, aged from 20-45, who were planned for elective cesarean section under spinal anethesia and allocated into 3 groups at random 25 parturients in each group. After the umbilical cord was clamped (group C: received i.v. 0.9% saline) , (group D: received 0.3ug/kg i.v. dexmedetomidine) and (group G: received 3mg i.v. granistron). The incidence and severity of postspinal shivering was our primary outcome and was evaluated by Tsai and Chu scale (Tsai et al .,2001), while the secondary outcomes were the changes in vital signs of the parturient before and after administration of tested drugs, sedation score and the occurrence of adverse effects of tested drug.