Prognostic Significance of Platelet Microparticles in Neonatal Sepsis

Background: Platelet microparticles (PMPs) play a role in inflammation and thrombosis during sepsis.Aim of the work : This study evaluated (PMPs) prognostic significance in neonatal sepsis (NS) and their relationship to clinical outcomes.Methods: This prospective case-control study included 85 neonates: 30 with NS, 30 with non-septic infections, and 25 healthy controls. PMP levels were measured using ELISA. Clinical and laboratory parameters were compared, and ROC curve analysis assessed the diagnostic performance of PMPs.Results: PMPs were significantly higher in NS compared to non-septic and control groups (p<0.05). ROC analysis revealed limited diagnostic power (cutoff 51×10³/µL, sensitivity 73.3%, specificity 63.3%). No significant correlation was found between PMPs and CRP, CBC, or liver/kidney functions. However, higher PMP levels were associated with mortality in NS (p<0.001).Conclusion: Elevated PMPs may have prognostic significance in neonatal sepsis, though their diagnostic accuracy is limited. Further studies are warranted to explore their role as biomarkers.