S2406 Autoimmune Hepatic Involvement in Systemic Sclerosis: Systematic Review and Meta-Analysis

Introduction: Systemic sclerosis (SSc) is a heterogeneous, multisystem autoimmune disease characterized by fibrosis in genetically predisposed individuals. It can involve multiple organ systems, but hepatic involvement is rare. In this study, we aim to find the correlation of liver disease, especially primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH), in the population with SSc. Further, the correlation of anti-mitochondrial antibody (AMA) and other autoantibodies was done. Methods: PubMed, Cochrane, Google Scholar, and Embase were searched for liver disease in SSc, and 11 studies were selected for analysis. Cochrane risk of bias tools and meta-analysis online were used. Controls were taken from the prevalence in the respective countries around the same time. Results: Among 11 studies including 2,797 patients with systemic sclerosis (SSc), 190 (6.7%) had liver disease, with 157 (5.6%) attributed to autoimmune causes. Primary biliary cholangitis (PBC) was the most common (5%), followed by autoimmune hepatitis (AIH) at 1.2%. PSC was only seen in 1 patient across the studies. There was a significant association in prevalence compared to the general population. Antimitochondrial antibodies (AMA) were positive in 10.87%, and anti-sp100 in 3.1%. Conclusion: The increased prevalence of autoimmune hepatobiliary conditions, such as primary biliary cholangitis (PBC), in systemic sclerosis (SSc) patients is likely due to overlapping immunopathogenic features, including shared regulatory T cell abnormalities and common genetic variants (e.g., STAT4, IRF5, NF-κB, IRF8). PBC was observed in approximately 5.6% of SSc patients—significantly higher than the general population prevalence of 0.02% to 0.04%—highlighting a strong association. This link is further supported by the presence of antimitochondrial antibodies (AMA) in 10.87% of patients, suggesting a high rate of subclinical or evolving PBC in this population. Autoimmune hepatitis (AIH) was identified in 1.2% of SSc patients. This rate exceeds general population estimates (0.02%–0.05%), suggesting that SSc may predispose patients to broader autoimmune liver involvement beyond PBC. Serological data revealed a substantial presence of liver-specific autoantibodies in SSc patients. In addition to AMA, anti-sp100 (3.1%) and anti-gp210 antibodies were frequently observed. These antibodies serve not only as diagnostic markers but may also offer prognostic value, reinforcing the link between SSc and autoimmune hepatobiliary pathology.