The EULAR points to consider regarding the development of criteria for the assessment of the disease activity in adult-onset Still’s disease

Objectives: This study aims to formulate European Alliance of Associations for Rheumatology (EULAR) points to consider (PtCs) regarding the development of criteria for the assessment of the disease activity in adult-onset Still´s disease (AOSD). Methods: The Task Force consisted of 23 members from 7 different European countries. A systematic literature review and a 3-round Delphi exercise involving European Experts were conducted to support the formulation of overarching principles and PtCs. Results: Based on retrieved evidence and Experts? opinions, results of Delphi Rounds, and discussions, 3 overarching principles and 11 PtCs were developed. The Task Force agreed on the importance of an appropriate definition for the disease activity in AOSD to be valid, reliable, and easily transferable in a clinical setting. The development of specific criteria for the assessment of disease activity should include a precise definition of the clinical features that could better describe the patient condition. A clear definition of disease activity would help clinicians to adjust therapy and to identify refractory patients. A validated assessment of the disease activity is important to establish specifically designed and powered studies for comprehensive management of patients with AOSD. A uniform and reproducible definition of remission may facilitate the inclusion of a new therapeutic target into daily practice and clinical trials. Conclusions: The EULAR PtCs were produced regarding the development of criteria for the assessment of the disease activity in AOSD, to provide the basis for a clinical tool to be readily, reliably, and easily applied in clinical settings in order to improve patient management.

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Publication Details

Journal
EULAR Rheumatology Open
Published
2025-12-01
DOI
https://doi.org/10.1016/j.ero.2025.11.015
Citations
1
Primary Topic
Autoimmune and Inflammatory Disorders Research
Type
article
Field-Weighted Citation Impact
1.77
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article

The EULAR points to consider regarding the development of criteria for the assessment of the disease activity in adult-onset Still’s disease

Dorothea Fell, Martin Krusche, Miguel Ángel González-Gay, Tanja Stamm et al.
1 citations
EULAR Rheumatology Open
Autoimmune and Inflammatory Disorders Research
1.77
article

The EULAR points to consider regarding the development of criteria for the assessment of the disease activity in adult-onset Still’s disease

Dorothea Fell, Martin Krusche, Miguel Ángel González-Gay, Tanja Stamm, Cem Gabay, Piero Ruscitti, Helene Alexanderson, Eugen Feist, Maud Wieczorek, Javier Llorca, Roberto Giacomelli, M. Körner, Nicolas Rosine, Tanita-Christina Wilhelmer, C Boström, Marco Gattorno, Stéphane Mitrovic, Pierre Quartier, Charlotte Girard, Valentin Ritschl, Birgit Barten, Bruno Fautrel, Angelo Ravelli, Francis Guillemin
article en
1 citations

Abstract

Objectives: This study aims to formulate European Alliance of Associations for Rheumatology (EULAR) points to consider (PtCs) regarding the development of criteria for the assessment of the disease activity in adult-onset Still´s disease (AOSD). Methods: The Task Force consisted of 23 members from 7 different European countries. A systematic literature review and a 3-round Delphi exercise involving European Experts were conducted to support the formulation of overarching principles and PtCs. Results: Based on retrieved evidence and Experts? opinions, results of Delphi Rounds, and discussions, 3 overarching principles and 11 PtCs were developed. The Task Force agreed on the importance of an appropriate definition for the disease activity in AOSD to be valid, reliable, and easily transferable in a clinical setting. The development of specific criteria for the assessment of disease activity should include a precise definition of the clinical features that could better describe the patient condition. A clear definition of disease activity would help clinicians to adjust therapy and to identify refractory patients. A validated assessment of the disease activity is important to establish specifically designed and powered studies for comprehensive management of patients with AOSD. A uniform and reproducible definition of remission may facilitate the inclusion of a new therapeutic target into daily practice and clinical trials. Conclusions: The EULAR PtCs were produced regarding the development of criteria for the assessment of the disease activity in AOSD, to provide the basis for a clinical tool to be readily, reliably, and easily applied in clinical settings in order to improve patient management.

EULAR Rheumatology Open
University of Geneva (CH), Universidad de Cantabria (ES), Karolinska University Hospital (SE), Inserm (FR), Università Campus Bio-Medico (IT), Institut Pasteur (FR), Universität Hamburg (DE), Université Paris Cité (FR), University of L'Aquila (IT), Istituto Giannina Gaslini (IT), Karolinska Institutet (SE), Sorbonne Université (FR), Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA (AT), Assistance Publique – Hôpitaux de Paris (FR), FORS – Swiss Centre of Expertise in the Social Sciences (CH), Centre de Référence des Maladies Autoinflammatoires et des Amyloses (FR), OSE Immunotherapeutics (France) (FR), University Hospital of Geneva (CH), University Medical Center Hamburg-Eppendorf (DE), Pitié-Salpêtrière Hospital (FR), Deutsche Rheuma-Liga (DE), Bipar (FR), Melun Hospital (FR), Hospital Universitario Fundación Jiménez Díaz (ES), Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR), Campus Bio Medico University Hospital (IT), European League Against Rheumatism (CH), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES), Immunologie - Immunopathologie - Immunothérapie (FR), Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est (FR), Ludwig Boltzmann Institute for Digital Health and Prevention (AT), Medical University of Vienna (AT), Université de Lorraine (FR), Otto-von-Guericke-Universität Magdeburg (DE)
Openalex Percentile: Top 10%
Autoimmune and Inflammatory Disorders Research
1.77
DOIOpen Access PDFOpenAlex
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