Folate Interaction With Genetic Risk for Neural Tube Defects Among Infants in Bangladesh
Inclusion of maternal folate intake as a covariate and interaction term identified three genomic loci that could impact the risk for SB. A fourth locus was identified when maternal arsenic level was included. These nominal associations should be assessed in additional cohorts with larger sample sizes. Novel genes impacted by these loci may interact with previously reported genes for SB.
Authors
- Kelly Liu
- Sheikh Muhammad Ekramullah
- Sarah U. Morton (ORCID: https://orcid.org/0000-0002-7816-2646)
- Hafiza Sultana Suchanda
- Afifah Farooque
- Maitreyi Mazumdar (ORCID: https://orcid.org/0000-0003-0380-2407)
- Sudipta Kumer Mukherjee (ORCID: https://orcid.org/0000-0003-4618-459X)
- Michael D. Uhler (ORCID: https://orcid.org/0000-0002-2518-8308)
- Enrique Mondragon‐Estrada (ORCID: https://orcid.org/0009-0004-5592-1728)
- DM Arman (ORCID: https://orcid.org/0009-0003-4755-4895)
- Joynul Islam (ORCID: https://orcid.org/0000-0001-6402-8668)
- David C. Christiani
- Benjamin C. Warf (ORCID: https://orcid.org/0000-0001-6376-4751)
- Xingyan Wang
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- National Institute of Neurosciences & Hospital (BD)
Publication Details
- Journal
- Birth Defects Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/bdr2.70007
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Environmental Health Sciences