Efficacy of immediate-release versus extended-release metformin on glycemic control and insulin resistance in Saudi patients with type 2 diabetes: A prospective cohort study
In newly diagnosed Saudi patients with T2DM, metformin XR showed better reduction in long-term glycemic control compared to IR, while both formulations similarly reduced insulin levels and resistance. XR's enhanced glycemic efficacy, achieved without differences in insulin resistance effects, may reflect improved adherence and sustained drug delivery.
Authors
- Tariq Alrasheed (ORCID: https://orcid.org/0009-0009-8239-5061)
- Hyder Osman Mirghani (ORCID: https://orcid.org/0000-0002-5817-6194)
- M.N. Somchit (ORCID: https://orcid.org/0000-0002-4710-3467)
- Hisham Alshadfan (ORCID: https://orcid.org/0000-0002-6827-939X)
Institutions
- Universiti Putra Malaysia (MY)
- University of Tabuk (SA)
Publication Details
- Journal
- Journal of Taibah University Medical Sciences
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jtumed.2025.11.005
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00