Hypoxia signaling pathway activation in osteoblasts suppresses osteocalcin production but does not alter male fertility in mice
These findings indicate that aberrant hypoxia signaling in bone suppresses OCN production without compromising male fertility, possibly reflecting a role for the broader physiological context as critical modulator of OCN's endocrine activity.
Authors
- Karen De Samblancx
- Vanessa Dubois (ORCID: https://orcid.org/0000-0001-8894-2980)
- Dirk Vanderschueren (ORCID: https://orcid.org/0000-0003-1395-0104)
- Sylvain Provot (ORCID: https://orcid.org/0000-0003-4087-4450)
- Christa Maes (ORCID: https://orcid.org/0000-0003-4243-5486)
- Roger Valle-Tenney (ORCID: https://orcid.org/0000-0002-0187-1460)
- Seppe Melis (ORCID: https://orcid.org/0000-0001-5681-7122)
- Naomi Dirckx (ORCID: https://orcid.org/0000-0001-6507-8106)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Ghent University Hospital (BE)
- Ghent University (BE)
- Bioscar (FR)
- Hôpital Lariboisière (FR)
- KU Leuven (BE)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1093/ejendo/lvaf249
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00