Balamuthia mandrillaris—EBV co-infective encephalitis diagnosed by MetaCAP: comparative mNGS validation and epidemiological landscape from 41 Chinese cases
This study reports a novel viral-amoebic co-infective GAE and validates MetaCAP as a highly sensitive diagnostic tool, outperforming mNGS for detecting fastidious pathogens. The integrated national cohort data provide critical insights into the disease's profile in China, suggesting that MetaCAP can significantly improve diagnostic yield and guide earlier intervention.
Authors
- Shuchen Lin
- Fei‐Fei Liu (ORCID: https://orcid.org/0000-0003-4344-6486)
- Zhiqiang Peng (ORCID: https://orcid.org/0000-0001-8130-162X)
- Fangmei Xie (ORCID: https://orcid.org/0000-0003-4939-0807)
- Zeping Han (ORCID: https://orcid.org/0000-0003-3804-7704)
- Pingping Zhang (ORCID: https://orcid.org/0009-0004-4634-4711)
- Xiaoyu Song (ORCID: https://orcid.org/0000-0002-6583-9400)
- Ling Chen (ORCID: https://orcid.org/0000-0003-1485-1626)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-6302-8383)
- Jinhua He (ORCID: https://orcid.org/0000-0003-4841-5179)
- Ying Zhao (ORCID: https://orcid.org/0000-0003-1713-5238)
- Wenfeng Luo (ORCID: https://orcid.org/0000-0003-0922-1005)
- Xiaoxiao He
- Fengming Guo
Institutions
- Kingmed Diagnostics (CN)
- Panyu District Central Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1016/j.ijid.2025.108302
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province