Association between Anti-Helicobacter pylori IgG seropositivity on coronary heart disease and potential pathogenesis: a Mendelian randomization study
Our MR study provided strong evidence of a causal relationship between anti-H. pylori IgG seropositivity and related to an increased risk of CHD. The effect of anti-H. pylori IgG seropositivity on CHD may be related to a higher peak insulin response or lower total free cholesterol levels and a decrease in waist circumference and waist-to-hip ratio. However, further research is needed to prove the results.
Authors
- Yingzi Cui
- Hongguang Jin
- Jinling Zhang (ORCID: https://orcid.org/0000-0003-3419-6542)
- Jing Wang (ORCID: https://orcid.org/0000-0001-7199-4784)
- Rui Chen (ORCID: https://orcid.org/0000-0002-0541-1824)
- Le Liu (ORCID: https://orcid.org/0000-0002-2820-027X)
- Yiqiang Wang (ORCID: https://orcid.org/0000-0002-2324-7116)
- Tianying Chang (ORCID: https://orcid.org/0000-0001-5635-9547)
Institutions
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1371/journal.pone.0329137
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00