Lactulose, a Disaccharide Prebiotic, Improves the Gut-Kidney Axis via Enhancement of Akkermansia Muciniphila Production
Our findings suggest that lactulose functions as an in vivo AKK inducer, exerting renoprotective effects by improving intestinal barrier function in CKD. These results highlight the potential of lactulose as a prebiotic therapeutic agent for CKD management.
Authors
- Moritaka Goto (ORCID: https://orcid.org/0000-0001-5376-4109)
- Daisuke Kadowaki (ORCID: https://orcid.org/0000-0001-5166-7145)
- Hiroshi Watanabe (ORCID: https://orcid.org/0000-0001-7620-1894)
- Kazutaka Matsushita
- Ebenezer Ofori-Attah (ORCID: https://orcid.org/0000-0002-4371-3698)
- Motoko Tanaka
- Hitoshi Maeda (ORCID: https://orcid.org/0000-0002-0794-9468)
- Toru Maruyama (ORCID: https://orcid.org/0000-0001-6543-4377)
- Takao Sato (ORCID: https://orcid.org/0000-0002-2802-6507)
- Mai Hashimoto
- Hideaki Jinnouchi (ORCID: https://orcid.org/0000-0002-7391-7966)
- Mayu Oki
- Miyu Sueyoshi
- Takehiro Nakano
Institutions
- Sojo University (JP)
- Akebono (Japan) (JP)
- Kyoto Pharmaceutical University (JP)
- Akebono Clinic (JP)
- Kumamoto Industrial Research Institute (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Kidney360
- Published
- 2025-12-09
- DOI
- https://doi.org/10.34067/kid.0000001040
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00