Heterogeneous impacts of HIV pre-exposure prophylaxis (PrEP) on drug resistance and phylogenetic cluster transmission dynamics in British Columbia, Canada: A retrospective cohort and simulation study
We estimated that the oral PrEP program in BC from 2018 to 2022 averted approximately 20 new HIV diagnoses per year across phylogenetic clusters, while infrequently contributing to baseline drug resistance in instances where PrEP was inadvertently prescribed during acute infection or with incomplete adherence. These findings corroborate the broad effectiveness of PrEP, describe heterogeneity in its impacts on clusters' growth, and suggest groups for prioritized PrEP services.
Authors
- Mark Hull (ORCID: https://orcid.org/0000-0002-9234-3531)
- Angela McLaughlin (ORCID: https://orcid.org/0000-0001-5606-9080)
- Rolando Barrios (ORCID: https://orcid.org/0000-0003-3642-5986)
- Vincent Montoya
- Junine Toy (ORCID: https://orcid.org/0000-0001-8803-3744)
- Jeffrey B. Joy (ORCID: https://orcid.org/0000-0002-7013-1482)
- Paul Sereda (ORCID: https://orcid.org/0000-0002-6411-8089)
- Jason Trigg (ORCID: https://orcid.org/0000-0002-7815-0725)
- Chanson J. Brumme (ORCID: https://orcid.org/0000-0003-2722-5288)
- Julio Montaner (ORCID: https://orcid.org/0000-0002-6201-9829)
Institutions
- University of British Columbia (CA)
- AIDS Vancouver (CA)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1371/journal.pmed.1004827
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00