Integrated bioinformatic and in vivo analysis confirms the cardioprotective role of OPA1
These results further demonstrate the important role of OPA1 in supporting optimal cardiac function and highlight potentially protective contractile and metabolic signaling pathways.
Authors
- Mary‐Ellen Harper (ORCID: https://orcid.org/0000-0003-3864-5886)
- Serena M. Pulente
- Miroslava Čuperlović‐Culf (ORCID: https://orcid.org/0000-0002-9483-8159)
- Erin E. Mulvihill (ORCID: https://orcid.org/0000-0002-3981-0241)
- Craig J. Goergen (ORCID: https://orcid.org/0000-0001-8883-7953)
- Claire Fong-McMaster (ORCID: https://orcid.org/0009-0007-5713-5386)
- Luke S Kennedy (ORCID: https://orcid.org/0000-0002-6895-5984)
- Tyler K.T. Smith (ORCID: https://orcid.org/0000-0002-8013-4660)
- Ilka Lorenzen‐Schmidt
- Martin Lévesque (ORCID: https://orcid.org/0000-0002-1547-3746)
- Morgan D. Fullerton (ORCID: https://orcid.org/0000-0002-7221-306X)
- Ella McIlroy
- Charbel Y Karam
- Stephanie Myers (ORCID: https://orcid.org/0000-0001-8235-9882)
- Michel N Kanaan
- Matthew Cope
Institutions
- University of Ottawa (CA)
- Queen's University (CA)
- Purdue University West Lafayette (US)
- National Research Council Canada (CA)
- Institute of Infection and Immunity (CA)
- Ottawa Institute of Systems Biology
- Ottawa University (US)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s12872-025-05413-0
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00