Association of cancer with neuropathological markers of Alzheimer's disease and related dementias
A prevalent diagnosis of cancer was associated with a lower risk of cognitive decline in older individuals.A prevalent diagnosis of cancer was associated with a lower risk of TDP-43 pathology and Lewy body pathology in older individuals.Effects of cancer on TDP-43 pathology were maintained when controlling for degree of cognitive decline.
Authors
- Stefan Johannes Teipel (ORCID: https://orcid.org/0000-0002-3586-3194)
- Jens Bohlken (ORCID: https://orcid.org/0000-0002-9576-7858)
- Manas K. Akmatov (ORCID: https://orcid.org/0000-0003-2310-3179)
- Jakob Holstiege (ORCID: https://orcid.org/0000-0003-1337-6640)
- Christian Junghanß (ORCID: https://orcid.org/0000-0003-4707-777X)
- Bernhard Michalowsky (ORCID: https://orcid.org/0000-0002-3425-0089)
Institutions
- Leipzig University of Applied Sciences (DE)
- German Center for Neurodegenerative Diseases (DE)
- Forschungszentrum für Verbrennungsmotoren und Thermodynamik Rostock (Germany) (DE)
- Rostock University of Music and Theatre (DE)
- Siemens Healthineers (Germany) (DE)
- University of Rostock (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70222
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging