Arsenic Sulfide Induces Apoptosis in Myelodysplastic Neoplasm Cells Through the Suppression of ABI2
The collective findings suggest that ABI2 is significantly overexpressed in MDS and AML, and its expression was correlated with unfavorable prognostic outcomes. Furthermore, As₂S₂ demonstrates therapeutic efficacy in MDS by modulating the expression levels of ABI2.
Authors
- Yuchen Tao
- Ning Ding (ORCID: https://orcid.org/0000-0001-6560-2967)
- Shuyang Cai
- Qian Ba (ORCID: https://orcid.org/0000-0002-7253-7566)
- Runfeng Ni (ORCID: https://orcid.org/0000-0003-0523-049X)
- Jianye Ren
- Yirong Chen (ORCID: https://orcid.org/0000-0002-5622-7939)
- Rui Jin (ORCID: https://orcid.org/0000-0001-5456-2381)
- Jiahui Lü (ORCID: https://orcid.org/0000-0002-0318-2335)
- Hao Xu (ORCID: https://orcid.org/0000-0002-8311-506X)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Biological Procedures Online
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s12575-025-00311-3
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00