Adipose–Muscle Crosstalk in COPD Cachexia: Early Adipose Atrophy Drives Subsequent Muscle Wasting
Our findings indicate that cigarette smoke-induced adipose tissue atrophy precedes muscle wasting, and alterations in adipose tissue may contribute to muscle atrophy progression. Adipose tissue dysfunction may be implicated in the development of cachexia in patients with COPD, highlighting its potential as a therapeutic target.
Authors
- Katsunori Masaki (ORCID: https://orcid.org/0000-0003-0909-9409)
- Naoya Tanabe (ORCID: https://orcid.org/0000-0002-7481-0212)
- Hiroki Kabata (ORCID: https://orcid.org/0000-0001-8853-6149)
- Tomoki Maetani (ORCID: https://orcid.org/0000-0001-5063-662X)
- Jun Miyata (ORCID: https://orcid.org/0000-0002-3189-1702)
- H. Iizuka
- Junko Hamamoto (ORCID: https://orcid.org/0000-0002-8054-0124)
- Koichiro Asano (ORCID: https://orcid.org/0000-0002-9044-3061)
- Yoshitake Yamada (ORCID: https://orcid.org/0000-0002-5842-5349)
- Masahiro Jinzaki (ORCID: https://orcid.org/0000-0002-8241-6565)
- Hidetoshi Nakamura (ORCID: https://orcid.org/0000-0001-7434-9764)
- Shotaro Chubachi (ORCID: https://orcid.org/0000-0002-5046-3762)
- Takashi Shimada (ORCID: https://orcid.org/0000-0003-3299-1630)
- Mamoru Sasaki (ORCID: https://orcid.org/0000-0002-5501-4245)
- Tetsuya Arai
- Kaori Sakurai (ORCID: https://orcid.org/0000-0002-1565-781X)
- Shiro Otake
- Nishikawa Keisuke
- Koichi Fukunaga
Institutions
- Tokai University (JP)
- Keio University (JP)
- Kyoto University (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jcsm.70154
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00