Harnessing Oxidized Alginate Microgels for Rapid and Self‐Assembling Dental Tissue Organogenesis In Vitro and In Vivo
Dental Tissue Organogenesis In article number 2500053, Zhaoming Wu, Sang Jin Lee, and co-workers investigate the use of modified fully biodegradable oxidized alginate microgels loaded with high-density dental cells to induce self-dental tissue organogenesis. Utilizing tooth-derived stem cells or embryonic cells, the system promotes self-tissue assembly in vitro, while in vivo validation demonstrates epithelial mesenchymal interactions and strong tissue integration with host tissue. This approach successfully facilitates robust 3D vascularized tissue formation and osteogenesis, highlighting significant potential for advancing craniofacial reconstruction.
Authors
- Zhaoming Wu (ORCID: https://orcid.org/0000-0002-0131-2423)
- Shuxuan Wu
- Indong Jun
- Zhenzhen Wu (ORCID: https://orcid.org/0000-0002-0647-9070)
- Feiming Li (ORCID: https://orcid.org/0009-0002-3963-4847)
- Chao Liang (ORCID: https://orcid.org/0000-0003-2278-1576)
- Honghyun Park (ORCID: https://orcid.org/0000-0002-0716-1507)
- Yiu Yan Leung (ORCID: https://orcid.org/0000-0002-6670-6570)
- Jae Seo Lee (ORCID: https://orcid.org/0000-0002-8266-8885)
- Il Keun Kwon (ORCID: https://orcid.org/0000-0001-9649-3003)
- Ann‐Na Cho (ORCID: https://orcid.org/0000-0003-0047-8867)
- Seil Sohn (ORCID: https://orcid.org/0000-0001-5724-8099)
- Gkk Leung (ORCID: https://orcid.org/0000-0003-3147-3057)
- Hwan Kim (ORCID: https://orcid.org/0000-0001-7656-9920)
- Karrie Mei Yee Kiang (ORCID: https://orcid.org/0000-0002-4354-9648)
- Haram Nah (ORCID: https://orcid.org/0000-0003-3807-5166)
- Siyuan Chen (ORCID: https://orcid.org/0009-0003-5852-5758)
- Sang-Woo Lee (ORCID: https://orcid.org/0000-0002-7445-5804)
- Sang Jin Lee (ORCID: https://orcid.org/0000-0002-8007-8785)
- Ziqi Huang (ORCID: https://orcid.org/0009-0004-7820-4852)
- Hee Jung Lee (ORCID: https://orcid.org/0000-0003-4128-1251)
- Seong Jun Kim (ORCID: https://orcid.org/0000-0001-5611-3133)
- Deok Rim Heo
Institutions
- Seoul National University of Science and Technology (KR)
- The University of Sydney (AU)
- Seoul National University (KR)
- Kyung Hee University (KR)
- KIST Europe (DE)
- Korea Institute of Materials Science (KR)
- CHA University Bundang Medical Center (KR)
- Kyung Hee University Dental Hospital (KR)
- Seoul National University Dental Hospital (KR)
- University of Hong Kong (HK)
Publication Details
- Journal
- Small Science
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/smsc.70156
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00