Potential neutrophil activation-related pathogenic genes in venous thromboembolism: a multi-omics Mendelian randomization study
This study identifies PLAU, ALOX12, and LGALS3 as genetically prioritized, causal-candidate genes for VTE, enhancing our understanding of immunothrombosis and providing promising targets for future therapeutic development.
Authors
- Ye Guo (ORCID: https://orcid.org/0000-0002-1813-9815)
- Weiling Shou
- L Zhang (ORCID: https://orcid.org/0000-0002-8403-0228)
- Qian Chen (ORCID: https://orcid.org/0000-0002-1487-5479)
- Shengli Sun (ORCID: https://orcid.org/0000-0003-0647-3696)
- J. Fang (ORCID: https://orcid.org/0000-0001-8091-626X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1097/js9.0000000000004473
- Citations
- 1
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.77