Mendelian randomization and transcriptomic analysis reveal a relationship between subarachnoid hemorrhage and post-translational modifications
The work established a novel ATG7-ZRANB1 biomarker combination with superior diagnostic accuracy for SAH prediction and identified Tretinoin as a promising therapeutic candidate, demonstrating PTM-based precision medicine potential.
Authors
- Ligang Song (ORCID: https://orcid.org/0000-0002-6444-4589)
- Ning Ma (ORCID: https://orcid.org/0000-0002-4909-7048)
- Xuan Sun (ORCID: https://orcid.org/0000-0001-8692-9838)
- Dapeng Mo
- Hengri Cong (ORCID: https://orcid.org/0009-0005-8476-8379)
- Miao Li (ORCID: https://orcid.org/0009-0000-8116-7598)
- Pei Wu (ORCID: https://orcid.org/0000-0002-1833-7555)
- Mingxuan Huang (ORCID: https://orcid.org/0009-0008-2383-9446)
- Xiaofeng Chen (ORCID: https://orcid.org/0000-0001-6577-5681)
- Hongwei He (ORCID: https://orcid.org/0000-0001-6042-7629)
- Hanlin Chen (ORCID: https://orcid.org/0000-0001-6205-3122)
- Yiming Deng (ORCID: https://orcid.org/0000-0002-2781-2290)
- Xiaoming Su (ORCID: https://orcid.org/0009-0005-2027-3473)
- Yi Su (ORCID: https://orcid.org/0009-0003-0925-3143)
- Ce Jiang
Institutions
- Harbin Medical University (CN)
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Institute of Neurosurgery (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1097/js9.0000000000004408
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00