Breaking the shields of resistance: multidimensional therapeutic strategies in the breast cancer drug resistance conundrum

Breast cancer remains a leading threat to women's health worldwide, and optimizing its treatment urgently requires the deep integration of multidimensional strategies. Current therapeutic regimens are founded on chemotherapeutic agents but are universally constrained by the dual challenges of evolving drug resistance and systemic toxicity. In this review, we summarize the clinical landscape and recent advances of commonly used breast cancer therapies. We further discuss innovative approaches to overcome resistance, including single-cell sequencing, nanotechnology, and targeted therapies. These methods are under active investigation and hold promise for improving treatment outcomes in breast cancer. This comprehensive discussion serves as a valuable resource for advancing breast cancer therapy and addressing the challenges of resistance.