Chinese Medicine Formula HJ11 Alleviates Atherosclerosis by Inactivating the TLR4/MyD88/IκB-α Pathway and Modulating the Heart-Gut Axis Response
HJ11 exerted protective effects on coronary atherosclerosis by reducing systemic serum lipid levels and inhibiting plaque formation, vascular inflammation, and collagen deposition, while also alleviating aortic injury. It suppressed endothelial inflammation and inhibited the proliferation of vascular smooth muscle cells. In the gut, HJ11 alleviated intestinal structural damage and enhanced barrier integrity. Notably, it promoted the function of Akkermansia, a beneficial bacterium known to influence TLR4 expression. Finally, in an in vitro atherosclerosis model, HJ11 decoction inhibited cell proliferation and migration by inactivating the TLR4/MYD88/IκB-α signaling pathway-an effect that was abolished by TLR4 overexpression.
Authors
- Weiming Xu (ORCID: https://orcid.org/0000-0002-7085-7814)
- Jiaxi Zou
- Mingfei Shi (ORCID: https://orcid.org/0000-0001-9458-0488)
- Ziyun Li
- Jingqing Hu (ORCID: https://orcid.org/0000-0002-8581-776X)
- Fangyuan Zhang (ORCID: https://orcid.org/0000-0002-2282-927X)
- Fei Lü (ORCID: https://orcid.org/0000-0003-2615-0122)
- Yuting Cui (ORCID: https://orcid.org/0000-0003-0746-1590)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
- Zhejiang Institute of Science and Technology Information (CN)
- Chinese Academy of Science and Technology for Development (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s523304
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00