Comparison of P53 Marker Expression Between Dentigerous Cyst and Calcifying Odontogenic Cyst

<i>Background</i><i>: </i>Calcifying odontogenic cyst is a developmental cyst that often appears in jaw cysts, and dentigerous cyst is the most common developmental cyst of the jaw, which has the ability to turn into a neoplasm. p53 is increased in some odontogenic cysts and tumors. The aim of this study is to compare the expression of P53 marker in dentigerous cyst and calcifying odontogenic cyst by immunohistochemical method. <i>Methods</i><i>: </i>In this descriptive-analytic cross-sectional study, the studied population is the sample of odontogenic dentigerous cysts and calcifying odontogenic cysts in the pathology center of urmia. First, all the files in the archive of the department from 2000 to 2021 were examined and the cases of cysts were examined separately and in terms of the expression of P53 marker in dentigerous cysts and calcifying odontogenic cysts by immunohistochemical method. <i>Results</i><i>: </i>The results showed that the overall mean expression of p-53 marker in dentigerous cyst group was 33.45 with a standard deviation of 11.86%, among which the lowest and highest expression of the said marker was 12% and 54%, respectively. The overall average expression of p-53 marker in the calcifying odontogenic cyst group is 59.55 with a standard deviation of 13.73%, among which the lowest and highest expression of the said marker was 30% and 87%, respectively. There is a statistically significant difference between dentigerous cyst patients and odontogenic calcifying cyst patients in terms of p-53 marker expression, and the said marker is more expressed in patients in the odontogenic calcifying cyst group compared to dentigerous cyst patients (p< 0.001) <i>Conclusions</i><i>: </i>It seems that this protein (p53) can probably be a suitable marker to confirm the ability to predict invasion in premalignant oral lesions such as cysts in odontogenic calcification patients.