RNA m6A-binding protein YTHDF2 regulates neoblast proliferation in planarian regeneration by targeting ASTACIN Signaling
These findings show that DjYTHDF2.2 promotes neoblast self-renewal and regeneration by targeting Djast mRNA for degradation, which is a novel m<sup>6</sup>A-dependent regulatory axis that is essential for stem cell maintenance and tissue regeneration in planarians. This study highlights the conserved role of YTHDF2-mediated post-transcriptional control in stem cell biology and regenerative mechanisms.
Authors
- Fulin Chen (ORCID: https://orcid.org/0000-0001-9956-7194)
- Weijiang Xue (ORCID: https://orcid.org/0000-0002-3060-4580)
- Yuan Hong Yu (ORCID: https://orcid.org/0000-0002-7123-669X)
- Hanxue Zheng
- Guangzhou Qu (ORCID: https://orcid.org/0000-0001-6569-2878)
- Xuhong Qian (ORCID: https://orcid.org/0000-0003-0394-1968)
- Linfeng Li (ORCID: https://orcid.org/0000-0001-6185-4999)
- Duan Lin
- Du Wang (ORCID: https://orcid.org/0000-0001-6982-5842)
- Siyi Zhu
- Mengdi Cheng
- Shiyue Liu (ORCID: https://orcid.org/0000-0003-2614-9631)
- Jiayi Chen
- Rui Lin (ORCID: https://orcid.org/0009-0007-9627-4258)
Institutions
- Northwest University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.006
- Primary Topic
- Planarian Biology and Electrostimulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00